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Exploring the Mutated Kinases for Chemoenzymatic Synthesis of N4-Modified Cytidine Monophosphates.

Molecules (Basel, Switzerland) - 9 Aug 2024

Koplūnaitė Martyna, Butkutė Kamilė, Stankevičiūtė Jonita, Meškys Rolandas

Abstract excerpt

Nucleosides, nucleotides, and their analogues are an important class of molecules that are used as substrates in research of enzymes and nucleic acid, or as antiviral and antineoplastic agents. Nucleoside phosphorylation is usually achieved with chemical methods; however, enzymatic phosphorylation is a viable alternative. Here, we present a chemoenzymatic synthesis of modified cytidine monophosphates, where a...

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PMID: 39202847
DOI: 10.3390/molecules29163767
PMCID: PMC11357392

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