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Thymidylate Kinase: An Old Topic Brings New Perspectives

1 Mar 2013

Abstract excerpt

Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5'-diphosphate (dTDP), which is then converted to thymidine 5'-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK). TMPK has an important function in cell proliferation and its enzyme kinetics and related structures...

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PMID: 23394555
DOI: 10.2174/0929867311320100006

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