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Article

Drosophila deoxyribonucleoside kinase mutants with enhanced ability to phosphorylate purine analogs.

Gene therapy - 1 Sept 2007

Knecht W, Rozpedowska E, Le Breton C, Willer M, Gojkovic Z, Sandrini M P B, Joergensen T, Hasholt L, Munch-Petersen B, Piskur J

Abstract excerpt

Transduced deoxyribonucleoside kinases (dNK) can be used to kill recipient cells in combination with nucleoside prodrugs. The Drosophila melanogaster multisubstrate dNK (Dm-dNK) displays a superior turnover rate and has a great plasticity regarding its substrates. We used directed evolution to create Dm-dNK mutants with increased specificity for several nucleoside analogs (NAs) used as anticancer or antiviral...

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Identifiers

PMID: 17581598
DOI: 10.1038/sj.gt.3302982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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