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Article

Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells.

Biochemical pharmacology - 1 Jul 2012

Amsailale Rachid, Van Den Neste Eric, Arts Angélique, Starczewska Eliza, Bontemps Françoise, Smal Caroline

Abstract excerpt

Deoxycytidine kinase (dCK) (EC 2.7.1.74) is a key enzyme in the activation of several therapeutic nucleoside analogs (NA). Its activity can be increased in vivo by Ser-74 phosphorylation, a property that could be used for enhancing NA activation and clinical efficacy. In line with this, studies with recombinant dCK showed that mimicking Ser-74 phosphorylation by a S74E mutation increases its activity toward...

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PMID: 22490700
DOI: 10.1016/j.bcp.2012.03.022

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Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells.PMID 22490700Read ↗

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