Article
Investigation of the substrate recognition of Drosophila melanogaster nucleoside kinase by site directed mutagenesis.
Nucleosides, nucleotides & nucleic acids - 1 Oct 2004
Solaroli N, Bjerke M, Johansson M, Karlsson A
Abstract excerpt
The deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) has a broad substrate specificity and a higher catalytic rate than other known deoxyribonucleoside kinases. Therefore it is a natural candidate for possible use as a suicide gene in combined gene/chemotherapy of cancer. We have performed site directed mutagenesis and tested different truncated forms of the enzyme in order to increase the affinity...
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