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Article

Fate induction in CD8 CAR T cells through asymmetric cell division

28 Aug 2024

Abstract excerpt

Early expansion and long-term persistence predict efficacy of chimeric antigen receptor T cells (CARTs)1–7, but mechanisms governing effector versus memory CART differentiation and whether asymmetric cell division induces differential fates in human CARTs remain unclear. Here we show that target-induced proximity labelling enables isolation of first-division proximal-daughter and distal-daughter CD8 CARTs that...

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PMID: 39198645
DOI: 10.1038/s41586-024-07862-7

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