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The midbody and midbody remnant: from cellular debris to signaling organelle with diagnostic and therapeutic potential

28 May 2025

Abstract excerpt

The midbody (MB), a transient structure formed during cytokinesis, has evolved from a mere structural component to a complex signaling organelle with diverse functions beyond cell division. Recent studies have revealed that jettisoned MB remnants (MBR) play crucial roles in intercellular communication, influencing cell fate decisions, particularly in stem cells and cancer. MBRs act as large extracellular...

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PMID: 40434898
DOI: 10.1091/mbc.e25-03-0120

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