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Article

T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology.

Immunity - 19 Oct 2012

King Carolyn G, Koehli Sabrina, Hausmann Barbara, Schmaler Mathias, Zehn Dietmar, Palmer Ed

Abstract excerpt

The strength of interactions between T cell receptors and the peptide-major histocompatibility complex (pMHC) directly modulates T cell fitness, clonal expansion, and acquisition of effector properties. Here we show that asymmetric T cell division is an important mechanistic link between increased signal strength, effector differentiation, and the ability to induce tissue pathology. Recognition of pMHC above a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23084359
DOI: 10.1016/j.immuni.2012.06.021
PMCID: PMC3622938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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