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Two-stage CD8+ CAR T-cell differentiation in patients with large B-cell lymphoma

6 May 2025

Abstract excerpt

Advancements in chimeric antigen receptor (CAR) T-cell therapy for treating diffuse large B-cell lymphoma (DLBCL) have been limited by an incomplete understanding of CAR T-cell differentiation in patients. Here, we show via single-cell, multi-modal, and longitudinal analyses, that CD8+ CAR T cells from DLBCL patients successfully treated with axicabtagene ciloleucel undergo two distinct waves of clonal expansion...

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PMID: 40328775
DOI: 10.1038/s41467-025-59298-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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