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Article

HER2 amplification subtype intrahepatic cholangiocarcinoma exhibits high mutation burden and T cell exhaustion microenvironment.

Journal of cancer research and clinical oncology - 28 Aug 2024

Pu Xiaohong, Li Lin, Xu Feng, Wang Ziyu, Fu Yao, Wu Hongyan, Ren Jun, Chen Jun, Sun Beicheng

Abstract excerpt

OBJECTIVE: This study aimed to establish a uniform standard for the interpretation of HER2 gene and protein statuses in intrahepatic cholangiocarcinoma (ICC). We also intended to explore the clinical pathological characteristics, molecular features, RNA expression and immune microenvironment of HER2-positive ICC. METHODS: We analyzed a cohort of 304 ICCs using immunohistochemistry (IHC) and fluorescence in situ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39198311
DOI: 10.1007/s00432-024-05894-0
PMCID: PMC11358322

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