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Article

Comprehensive Immunogenomic Profiling of IDH1-/2-Altered Cholangiocarcinoma.

JCO precision oncology - 1 Mar 2024

Makawita Shalini, Lee Sunyoung, Kong Elisabeth, Kwong Lawrence N, Abouelfetouh Zeyad, Danner De Armas Anaemy, Xiao Lianchun, Murugesan Karthikeyan, Danziger Natalie, Pavlick Dean, Korkut Anil, Ross Jeffrey S, Javle Milind

Abstract excerpt

PURPOSE: Isocitrate dehydrogenase (IDH)1/2 genomic alterations (GA) occur in 20% of intrahepatic cholangiocarcinoma (iCCA); however, the immunogenomic landscape of IDH1-/2-mutated iCCA is largely unknown. METHODS: Comprehensive genomic profiling (CGP) was performed on 3,067 cases of advanced iCCA. Tumor mutational burden (TMB), PD-L1 expression (Dako 22C3), microsatellite instability (MSI), and genomic loss of...

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Share to B7-H1 Antigen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 38547421
DOI: 10.1200/PO.23.00544
PMCID: PMC10994443

Genes

IDH1
IDH2
CD70

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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