Article
Deficiency of interleukin-1 receptor antagonist in mice differentially affects bone properties under different genomic backgrounds.
Scientific reports - 27 Aug 2024
Dong Wei, Tian Cheng, Li Z Galvin, Bounds Matthew, Ma Jiamin, Brand David D, Liu Xiaoyun, Cao Yanhong, Beard Arielle, Yan Jian, Hasty Karen, Stuart John, Li Kui, Cho Hongsik, Fitzpatrick Elizabeth A, Myers Linda K, Jiao Yan, Gu Weikuan
Abstract excerpt
When IL-1 receptor antagonist (IL-1rn) is knocked out, mice have shown strain background dependent and major QTL regulated susceptibility to spontaneously inflammatory arthritis disease (SAD). The impact on bone properties resulting from the interactions of IL-1rn, genomic background strains, and the QTL locus, is unknown. Bone properties in the four specifically bred mouse strains with mutation of IL-1rn and...
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