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Article

Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase.

Nucleic acids research - 14 Oct 2024

Abbouche Lara, Murphy Vincent J, Gao Jixuan, van Twest Sylvie, Sobinoff Alexander P, Auweiler Karen M, Pickett Hilda A, Bythell-Douglas Rohan, Deans Andrew J

Abstract excerpt

FANCM is a DNA repair protein that recognizes stalled replication forks, and recruits downstream repair factors. FANCM activity is also essential for the survival of cancer cells that utilize the Alternative Lengthening of Telomeres (ALT) mechanism. FANCM efficiently recognizes stalled replication forks in the genome or at telomeres through its strong affinity for branched DNA structures. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39189453
DOI: 10.1093/nar/gkae727
PMCID: PMC11472164

Genes

FANCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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