Article
Molecular basis of a novel oncogenic mutation in GNAO1.
Oncogene - 9 Jun 2011
Garcia-Marcos M, Ghosh P, Farquhar M G
Abstract excerpt
Heterotrimeric G proteins are molecular switches that control signal transduction, and their dysregulation can promote oncogenesis. Somatic mutations in GNAS, GNAI2 and GNAQ genes induce oncogenesis by rendering Gα subunits constitutively activated. Recently the first somatic mutation, arginine(243) → histidine (R243H) in the GNAO1 (Gαo) gene was identified in breast carcinomas and shown to promote oncogenic...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Arginine
- Binding Sites
- Biocatalysis
- Cell Line, Tumor
- Cell Transformation, Neoplastic
- GTP-Binding Protein alpha Subunits, Gi-Go
- GTPase-Activating Proteins