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Article

Contract to kill: GNAS mutation.

Molecular cancer - 7 Mar 2025

Raut Pratima, Mathivanan Poompozhil, Batra Surinder K, Ponnusamy Moorthy P

Abstract excerpt

The mutation in Gsα-coding GNAS exons, popular as gsp oncogene, is the most frequent mutation across all heterotrimeric G proteins involved in oncogenesis. GNAS R201, the most frequently mutated, followed by Q227, are found predominantly across various neoplasms and cancers such as IPMN, pituitary, thyroid, appendiceal, colorectal, etc. This review emphasizes the pivotal significance of the gsp oncogene and its...

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Identifiers

PMID: 40050874
DOI: 10.1186/s12943-025-02247-4
PMCID: PMC11887407

Genes

GNAS

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