Mutated G proteins as drug targets.

Abstract excerpt

G proteins, members of the GTPase superfamily, are central mediators of signal transduction downstream of G protein-coupled receptors (GPCRs). Despite their critical roles in normal physiology and the high intrinsic affinity for endogenous ligands, G proteins have traditionally been considered 'undruggable'. Recent advances have led to the development of small molecules and peptides targeting wild-type (WT) G...

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