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Article

Regression convolutional neural network models implicate peripheral immune regulatory variants in the predisposition to Alzheimer's disease.

PLoS computational biology - 1 Aug 2024

Ramamurthy Easwaran, Agarwal Snigdha, Toong Noelle, Sestili Heather, Kaplow Irene M, Chen Ziheng, Phan BaDoi, Pfenning Andreas R

Abstract excerpt

Alzheimer's disease (AD) involves aggregation of amyloid β and tau, neuron loss, cognitive decline, and neuroinflammatory responses. Both resident microglia and peripheral immune cells have been associated with the immune component of AD. However, the relative contribution of resident and peripheral immune cell types to AD predisposition has not been thoroughly explored due to their similarity in gene expression...

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Identifiers

PMID: 39186798
DOI: 10.1371/journal.pcbi.1012356
PMCID: PMC11389932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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