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Maternal Helminth Infection Causes Dysfunctional B Cell Development in Male Offspring

26 Aug 2024

Abstract excerpt

Infections during pregnancy are known to trigger alterations in offspring immunity, often leading to increased disease susceptibility. Maternal helminth infections correlate with lower Ab titers to certain childhood immunizations and putative decreased vaccine efficacy. The mechanisms that underlie how maternal infection blunts offspring humoral responses are unclear. Using our murine model of maternal...

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PMID: 39185897
DOI: 10.4049/jimmunol.2400158

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