Article
Prenatal cadmium exposure produces persistent changes to thymus and spleen cell phenotypic repertoire as well as the acquired immune response.
Toxicology and applied pharmacology - 1 Dec 2012
Holásková Ida, Elliott Meenal, Hanson Miranda L, Schafer Rosana, Barnett John B
Abstract excerpt
Cadmium (Cd) is a common environmental contaminant. Adult exposure to Cd alters the immune system, however, there are limited studies on the effects of prenatal exposure to Cd. Pregnant C57Bl/6 mice were exposed to an environmentally relevant dose of CdCl(2) (10 ppm) and the effects on the immune system of the offspring were assessed at 20 weeks of age. Prenatal Cd exposure caused an increase in the percent of...
Topics
- Adaptive Immunity
- Animals
- Antibodies, Bacterial
- Bacterial Vaccines
- Cadmium
- Cadmium Poisoning
- Cohort Studies
- Female
- Flow Cytometry
- Male
- Maternal Exposure
- Mice
- Mice, Inbred C57BL
- Phenotype