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Article

The causal association between lipid-lowering strategies and risk of intracranial aneurysms: A drug-target Mendelian randomization study.

Journal of clinical lipidology - 1 Jan 2025

Zhou Da, Song Jiahao, Han Guangyu, Zhang Xiaoming, Ji Xunming, Meng Ran

Abstract excerpt

BACKGROUND: Observational studies have suggested potential correlations between unfavorable lipid profiles and the occurrence of intracranial aneurysms (IAs), proposing that lipid-lowering therapies might curb IA progression and prevent rupture. This study aimed to explore the causal impacts of lipid-reducing strategies on the risk of IAs. METHODS: We employed 3 genetic tools as proxies for our exposures and...

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Share to Cholesterol, LDL
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39979134
DOI: 10.1016/j.jacl.2025.01.003

Genes

PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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