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Article

MEF2B C-terminal mutations enhance transcriptional activity and stability to drive B cell lymphomagenesis.

Nature communications - 21 Aug 2024

Yu Chuanjiang, Shen Qiong, Holmes Antony B, Mo Tongwei, Tosato Anna, Soni Rajesh Kumar, Corinaldesi Clarissa, Koul Sanjay, Pasqualucci Laura, Hussein Shafinaz, Forouhar Farhad, Dalla-Favera Riccardo, Basso Katia

Abstract excerpt

The myocyte enhancer factor 2B (MEF2B) transcription factor is frequently mutated in germinal center (GC)-derived B-cell lymphomas. Its ammino (N)-terminal mutations drive lymphomagenesis by escaping interaction with transcriptional repressors, while the function of carboxy (C)-terminal mutations remains to be elucidated. Here, we show that MEF2B C-tail is physiologically phosphorylated at specific residues and...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, B-Cell

Share to MEF2 Transcription Factors

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Source

Open in PubMed Open full text

Identifiers

PMID: 39179580
DOI: 10.1038/s41467-024-51644-8
PMCID: PMC11343756

Genes

GC
CUL3
KLHL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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