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Article

MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation.

Nature communications - 6 Aug 2015

Pon Julia R, Wong Jackson, Saberi Saeed, Alder Olivia, Moksa Michelle, Grace Cheng S-W, Morin Gregg B, Hoodless Pamela A, Hirst Martin, Marra Marco A

Abstract excerpt

Myocyte enhancer factor 2B (MEF2B) is a transcription factor with mutation hotspots at K4, Y69 and D83 in diffuse large B-cell lymphoma (DLBCL). To provide insight into the regulatory network of MEF2B, in this study, we analyse global gene expression and DNA-binding patterns. We find that candidate MEF2B direct target genes include RHOB, RHOD, CDH13, ITGA5 and CAV1, and that indirect target genes of MEF2B include...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epithelial-Mesenchymal Transition

Share to Lymphoma, Large B-Cell, Diffuse

Share to MEF2 Transcription Factors

Share to Proto-Oncogene Proteins c-bcl-6

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 26245647
DOI: 10.1038/ncomms8953
PMCID: PMC4918335

Genes

CARD11
CAV1
CDH13
ITGA5
MYC
RHOB
RHOD
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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