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Article

MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma.

Nature immunology - 1 Oct 2013

Ying Carol Y, Dominguez-Sola David, Fabi Melissa, Lorenz Ivo C, Hussein Shafinaz, Bansal Mukesh, Califano Andrea, Pasqualucci Laura, Basso Katia, Dalla-Favera Riccardo

Abstract excerpt

MEF2B encodes a transcriptional activator and is mutated in ∼11% of diffuse large B cell lymphomas (DLBCLs) and ∼12% of follicular lymphomas (FLs). Here we found that MEF2B directly activated the transcription of the proto-oncogene BCL6 in normal germinal-center (GC) B cells and was required for DLBCL proliferation. Mutation of MEF2B resulted in enhanced transcriptional activity of MEF2B either through disruption...

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Share to Germinal Center
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Large B-Cell, Diffuse

Share to MADS Domain Proteins

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Share to Proto-Oncogene Proteins c-bcl-6

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Source

Open in PubMed Open full text

Identifiers

PMID: 23974956
DOI: 10.1038/ni.2688
PMCID: PMC3954820

Genes

BCL6
CABIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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