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Article

A novel MEF2C mutation in lymphoid neoplasm diffuse large B-cell lymphoma promotes tumorigenesis by increasing c-JUN expression.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Aug 2020

Jingjing Zhao, Lei Miao, Jie Zhang, Sha Cao, Yapeng Hu, Weimin Zhang, Chunluan Yuan

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is the most aggressive non-Hodgkin lymphoma (NHL), accounting for about 31% of the newly diagnosed NHL worldwide. Although approximately 60% of patients who initially received a standard R-CHOP treatment likely have a 3-year event-free survival, many patients become refractory or relapsed due to the genetic heterogeneity of this malignancy. Hence, new treatment strategies are...

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Identifiers

PMID: 31900516
DOI: 10.1007/s00210-019-01764-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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