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Article

Real-time identification of epistatic interactions in SARS-CoV-2 from large genome collections.

Genome biology - 22 Aug 2024

Innocenti Gabriel, Obara Maureen, Costa Bibiana, Jacobsen Henning, Katzmarzyk Maeva, Cicin-Sain Luka, Kalinke Ulrich, Galardini Marco

Abstract excerpt

BACKGROUND: The emergence of the SARS-CoV-2 virus has highlighted the importance of genomic epidemiology in understanding the evolution of pathogens and guiding public health interventions. The Omicron variant in particular has underscored the role of epistasis in the evolution of lineages with both higher infectivity and immune escape, and therefore the necessity to update surveillance pipelines to detect them...

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Share to COVID-19
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Mutation

Share to SARS-CoV-2

Share to Sequence Alignment

Share to Spike Glycoprotein, Coronavirus

Source

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Identifiers

PMID: 39175058
DOI: 10.1186/s13059-024-03355-y
PMCID: PMC11342480

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