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Article

Coordinated evolution at amino acid sites of SARS-CoV-2 spike.

eLife - 8 Feb 2023

Neverov Alexey Dmitrievich, Fedonin Gennady, Popova Anfisa, Bykova Daria, Bazykin Georgii

Abstract excerpt

SARS-CoV-2 has adapted in a stepwise manner, with multiple beneficial mutations accumulating in a rapid succession at origins of VOCs, and the reasons for this are unclear. Here, we searched for coordinated evolution of amino acid sites in the spike protein of SARS-CoV-2. Specifically, we searched for concordantly evolving site pairs (CSPs) for which changes at one site were rapidly followed by changes at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36752391
DOI: 10.7554/eLife.82516
PMCID: PMC9908078

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