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Mutations in viral nucleocapsid protein and endoRNase are discovered to associate with COVID19 hospitalization risk.

Scientific reports - 24 Jan 2022

Zhao Lue Ping, Roychoudhury Pavitra, Gilbert Peter, Schiffer Joshua, Lybrand Terry P, Payne Thomas H, Randhawa April, Thiebaud Sara, Mills Margaret, Greninger Alex, Pyo Chul-Woo, Wang Ruihan, Li Renyu, Thomas Alexander, Norris Brandon, Nelson Wyatt C, Jerome Keith R, Geraghty Daniel E

Abstract excerpt

SARS-CoV-2 is spreading worldwide with continuously evolving variants, some of which occur in the Spike protein and appear to increase viral transmissibility. However, variants that cause severe COVID-19 or lead to other breakthroughs have not been well characterized. To discover such viral variants, we assembled a cohort of 683 COVID-19 patients; 388 inpatients ("cases") and 295 outpatients ("controls") from...

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Identifiers

PMID: 35075180
DOI: 10.1038/s41598-021-04376-4
PMCID: PMC8786941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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