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Article

Dominant clade-featured SARS-CoV-2 co-occurring mutations reveal plausible epistasis: An in silico based hypothetical model.

Journal of medical virology - 1 Mar 2022

Alam A S M Rubayet Ul, Islam Ovinu Kibria, Hasan Md Shazid, Islam Mir Raihanul, Mahmud Shafi, Al-Emran Hassan M, Jahid Iqbal Kabir, Crandall Keith A, Hossain M Anwar

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into eight fundamental clades with four of these clades (G, GH, GR, and GV) globally prevalent in 2020. To explain plausible epistatic effects of the signature co-occurring mutations of these circulating clades on viral replication and transmission fitness, we proposed a hypothetical model using in silico approach. Molecular docking and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34676891
DOI: 10.1002/jmv.27416
PMCID: PMC8661685

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