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Global analysis of more than 50,000 SARS-CoV-2 genomes reveals epistasis between eight viral genes

17 Nov 2020

Abstract excerpt

Genome-wide epistasis analysis is a powerful tool to infer gene interactions, which can guide drug and vaccine development and lead to deeper understanding of microbial pathogenesis. We have considered all complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes deposited in the Global Initiative on Sharing All Influenza Data (GISAID) repository until four different cutoff dates, and used...

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PMID: 33203681
DOI: 10.1073/pnas.2012331117

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