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Article

The Role of Matrix Stiffness and Viscosity on Lipid Phenotype and Fat Lineage Potential.

Tissue engineering. Part A - 1 Jul 2025

Stephens Chelsea J, Kobayashi Reina, Berry Daniel C, Butcher Jonathan T

Abstract excerpt

Autologous fat transfer is a common procedure that patients undergo to rejuvenate large soft tissue defects. However, these surgeries are complicated by limited tissue sources, donor-site morbidity, and necrosis. While the biofabrication of fat tissue can serve as a clinical option for reconstructive surgery, the influence of matrix mechanics, specifically stiffness and viscosity, on adipogenesis requires further...

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Adipogenesis
Adipose Tissue
Cell Lineage
Extracellular Matrix
Gelatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipid Metabolism

Mesenchymal Stem Cells

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Identifiers

PMID: 39165245
DOI: 10.1089/ten.TEA.2024.0149
PMCID: PMC12394808

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