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Article

ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs.

Scientific reports - 17 Feb 2016

Lee Michelle H, Goralczyk Anna G, Kriszt Rókus, Ang Xiu Min, Badowski Cedric, Li Ying, Summers Scott A, Toh Sue-Anne, Yassin M Shabeer, Shabbir Asim, Sheppard Allan, Raghunath Michael

Abstract excerpt

Key to realizing the diagnostic and therapeutic potential of human brown/brite adipocytes is the identification of a renewable, easily accessible and safe tissue source of progenitor cells, and an efficacious in vitro differentiation protocol. We show that macromolecular crowding (MMC) facilitates brown adipocyte differentiation in adult human bone marrow mesenchymal stem cells (bmMSCs), as evidenced by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26883894
DOI: 10.1038/srep21173
PMCID: PMC4756694

Genes

UCP1
ATF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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