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Article

Matrix density regulates adipocyte phenotype.

Adipocyte - 1 Dec 2023

Ky Alexander, McCoy Atticus J, Flesher Carmen G, Friend Nicole E, Li Jie, Akinleye Kore, Patsalis Christopher, Lumeng Carey N, Putnam Andrew J, O'Rourke Robert W

Abstract excerpt

Alterations of the extracellular matrix contribute to adipose tissue dysfunction in metabolic disease. We studied the role of matrix density in regulating human adipocyte phenotype in a tunable hydrogel culture system. Lipid accumulation was maximal in intermediate hydrogel density of 5 weight %, relative to 3% and 10%. Adipogenesis and lipid and oxidative metabolic gene pathways were enriched in adipocytes in 5%...

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Identifiers

PMID: 37815174
DOI: 10.1080/21623945.2023.2268261
PMCID: PMC10566443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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