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Article

Lipids, Apolipoproteins, Lipid-Lowering Drugs, and the Risk of Cerebral Small Vessel Disease: A Mendelian Randomization Study.

Journal of the American Heart Association - 20 Aug 2024

Xie Yi, Liu Shuai, Wang Xinyue, Huang Hao, Wang Minghuan, Qu Wensheng, Yu Zhiyuan, Wang Wei, Luo Xiang

Abstract excerpt

BACKGROUND: Serum lipids are causally involved in the occurrence of atherosclerosis, but their roles in cerebral small vessel disease remain unclear. This study aimed to investigate the causal roles of lipid or apolipoprotein traits in cerebral small vessel disease and to determine the effects of lipid-lowering interventions on this disease. METHODS AND RESULTS: Data on genetic instruments of...

Topics

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Apolipoproteins
Cerebral Small Vessel Diseases
Cholesterol Ester Transfer Proteins
Cholesterol, HDL
Hypolipidemic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

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Identifiers

PMID: 39158561
DOI: 10.1161/JAHA.123.032409
PMCID: PMC11963954

Genes

CETP
HMGCR

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