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Article

Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol.

Brain : a journal of neurology - 1 Feb 2020

Georgakis Marios K, Malik Rainer, Anderson Christopher D, Parhofer Klaus G, Hopewell Jemma C, Dichgans Martin

Abstract excerpt

Blood lipids are causally involved in the pathogenesis of atherosclerosis, but their role in cerebral small vessel disease remains largely elusive. Here, we explored associations of genetic determinants of blood lipid levels, lipoprotein particle components, and targets for lipid-modifying drugs with small vessel disease phenotypes. We selected genetic instruments for blood levels of high-density lipoprotein...

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Identifiers

PMID: 31968102
DOI: 10.1093/brain/awz413
PMCID: PMC7009571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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