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Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

11 Apr 2017

Abstract excerpt

-mutant cancer cells is being targeted with platinum drugs and poly (ADP-ribose) polymerase (PARP) inhibitors. We have employed relatively simple and sensitive assays to determine the function of BRCA1 variants or mutants in two HDR mechanisms, homologous recombination (HR) and single strand annealing (SSA), and in conferring resistance to cisplatin and olaparib in human cancer cells. Our results define the...

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PMID: 28398198
DOI: 10.7554/elife.21350

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