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Article

A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics

29 Mar 2022

Abstract excerpt

Accumulating evidence suggests that senescence of kidney tubule epithelial cells leads to fibrosis. These cells secrete senescence-associated secretory phenotype (SASP) factors that are involved in diverse signaling pathways, influencing kidney fibrosis. Here, we investigated whether our previously established conditionally immortalized proximal tubule epithelial cell line overexpressing the organic anion...

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Share to Epigenetics and DNA Methylation
Share to Renal and related cancers
Share to Telomeres, Telomerase, and Senescence

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PMID: 35422705
DOI: 10.3389/fphar.2022.791612

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