Cortical Excitability as a Prognostic and Phenotypic Stratification Biomarker in Amyotrophic Lateral Sclerosis.

doi:10.1002/ana.27305

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Article

Cortical Excitability as a Prognostic and Phenotypic Stratification Biomarker in Amyotrophic Lateral Sclerosis.

Annals of neurology - 1 Oct 2025

Ranieri Federico, Senerchia Gianmaria, Bonan Luigi, Casali Stefania, Cabona Corrado, Cantone Mariagiovanna, De Marchi Fabiola, Diamanti Luca, Doretti Alberto, Fini Nicola, Filosto Massimiliano, Fortuna Andrea, Iovino Aniello, Iuzzolino Valentina Virginia, Lanza Giuseppe, Lunetta Christian, Maderna Luca, Mandrioli Jessica, Mazzini Letizia, Musumeci Gabriella, Nuredini Andi, Sorarù Gianni, Toriello Antonella, Ticozzi Nicola, Todisco Massimiliano, Vacchiano Veria, Zinno Lucia, Silani Vincenzo, Rossi Simone, Di Lazzaro Vincenzo, Dubbioso Raffaele

Abstract excerpt

OBJECTIVE: Despite its clinical heterogeneity, amyotrophic lateral sclerosis is unified by early and prominent alterations in cortical excitability, increasingly recognized as contributors to disease progression. This study assessed whether the ratio between motor evoked potential (MEP) amplitude, reflecting upper motor neuron integrity, and compound muscle action potential (CMAP) amplitude, indexing lower motor...

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PMID: 40557915
DOI: 10.1002/ana.27305
PMCID: PMC12542322

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