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Article

Cortical hyperexcitability in patients with C9ORF72 mutations: Relationship to phenotype.

Muscle & nerve - 1 Aug 2016

Schanz Olivia, Bageac Devin, Braun Laura, Traynor Bryan J, Lehky Tanya J, Floeter Mary Kay

Abstract excerpt

INTRODUCTION: Patients with mutations in C9orf72 can have amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), or ALS-FTD. The goals were to establish whether cortical hyperexcitability occurs in C9orf72 patients with different clinical presentations. METHODS: Cortical thresholds and silent periods were measured in thenar muscles in 19 participants with C9orf72 expansions and 21 healthy controls...

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Share to C9orf72 Protein
Share to Cerebral Cortex
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evoked Potentials, Motor

Share to Frontotemporal Dementia

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Identifiers

PMID: 26799151
DOI: 10.1002/mus.25047
PMCID: PMC4940214

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