Article
Bridging the gap between molecular and genomic epidemiology in tuberculosis: inferring MIRU-VNTR patterns from genomic data.
Journal of clinical microbiology - 11 Sept 2024
Buenestado-Serrano Sergio, Martínez-Lirola Miguel, Dippenaar Anzaan, Sanz-Pérez Amadeo, Garrido-Cárdenas José Antonio, Esteban-García Ana Belén, García-Toledo Adriana Justine, Rodríguez-Grande Cristina, Herranz-Martín Marta, Saleeb Sheri M, Muñoz Patricia, Warren Robin M, Pérez-Lago Laura, García de Viedma Darío
Abstract excerpt
The transition from MIRU-VNTR-based epidemiology studies in tuberculosis (TB) to genomic epidemiology has transformed how we track transmission. However, short-read sequencing is poor at analyzing repetitive regions such as the MIRU-VNTR loci. This causes a gap between the new genomic data and the large amount of information stored in historical databases. Long-read sequencing could bridge this knowledge gap by...
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