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Article

The Role of EREG/EGFR Pathway in Tumor Progression.

International journal of molecular sciences - 27 Nov 2021

Cheng Wan-Li, Feng Po-Hao, Lee Kang-Yun, Chen Kuan-Yuan, Sun Wei-Lun, Van Hiep Nguyen, Luo Ching-Shan, Wu Sheng-Ming

Abstract excerpt

Aberrant activation of the epidermal growth factor receptor (EGFR/ERBB1) by erythroblastic leukemia viral oncogene homolog (ERBB) ligands contributes to various tumor malignancies, including lung cancer and colorectal cancer (CRC). Epiregulin (EREG) is one of the EGFR ligands and is low expressed in most normal tissues. Elevated EREG in various cancers mainly activates EGFR signaling pathways and promotes cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34884633
DOI: 10.3390/ijms222312828
PMCID: PMC8657471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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