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Article

The cumulative effects of known susceptibility variants to predict primary biliary cirrhosis risk.

Genes and immunity - 1 Jan 2000

Tang R, Chen H, Miao Q, Bian Z, Ma W, Feng X, Seldin M F, Invernizzi P, Gershwin M E, Liao W, Ma X

Abstract excerpt

Multiple genetic variants influence the risk for development of primary biliary cirrhosis (PBC). To explore the cumulative effects of known susceptibility loci on risk, we utilized a weighted genetic risk score (wGRS) to evaluate whether genetic information can predict susceptibility. The wGRS was created using 26 known susceptibility loci and investigated in 1840 UK PBC and 5164 controls. Our data indicate that...

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Identifiers

PMID: 25569263
DOI: 10.1038/gene.2014.76
PMCID: PMC5553973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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