Article
Alternative Splicing in Genetic Diseases: Improved Diagnosis and Novel Treatment Options.
International review of cell and molecular biology - 1 Jan 2018
Bergsma Atze J, van der Wal Erik, Broeders Mike, van der Ploeg Ans T, Pim Pijnappel W W M
Abstract excerpt
Alternative splicing is an important mechanism to regulate gene expression and to expand the repertoire of gene products in order to accommodate an increase in complexity of multicellular organisms. It needs to be precisely regulated, which is achieved via RNA structure, splicing factors, transcriptional regulation, and chromatin. Changes in any of these factors can lead to disease. These may include the core...
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