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Article

Molecular and Clinicopathologic Impact of GNAS Variants Across Solid Tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Nov 2024

Johannet Paul, Abdelfattah Somer, Wilde Callahan, Patel Shrey, Walch Henry, Rousseau Benoit, Argiles Guillem, Artz Oliver, Patel Miteshkumar, Arfe Andrea, Cercek Andrea, Yaeger Rona, Ganesh Karuna, Schultz Nikolaus, Diaz Luis A, Foote Michael B

Abstract excerpt

PURPOSE: The molecular drivers underlying mucinous tumor pathogenicity are poorly understood. GNAS mutations predict metastatic burden and treatment resistance in mucinous appendiceal adenocarcinoma. We investigated the pan-cancer clinicopathologic relevance of GNAS variants. METHODS: We assessed 58,043 patients with Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets...

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Topics

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Share to Adenocarcinoma, Mucinous
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers, Tumor

Share to Chromogranins

Share to GNAS gene

Share to GTP-Binding Protein alpha Subunits, Gs

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Source

Open in PubMed Open full text

Identifiers

PMID: 39121438
DOI: 10.1200/JCO.24.00186
PMCID: PMC11540749

Genes

GNAS
IMPACT
INPPL1
KRAS
RBM10
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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