Article
Peritoneal metastases from primary appendiceal and colorectal carcinomas demonstrate distinct molecular identities on comprehensive tumor analysis.
Journal of surgical oncology - 1 Apr 2023
Fleming Andrew M, Deschner Benjamin W, Williard Forrest W, Drake Justin A, Vanderwalde Ari, Xiu Joanne, Somer Bradley G, Yakoub Danny, Tsao Miriam W, Glazer Evan S, Dickson Paxton V, Shibata David, Philip Philip A, Hwang Jimmy J, Shields Anthony F, Marshall John L, Korn W Michael, Lenz Heinz-Josef, Deneve Jeremiah L
Abstract excerpt
BACKGROUND AND OBJECTIVES: Published data comparing peritoneal metastases from appendiceal cancers (pAC) and colorectal cancers (pCRC) remain sparse. We compared pAC and pCRC using comprehensive tumor profiling (CTP). METHODS: CTP was performed, including next-generation sequencing and analysis of copy number variation (CNV), microsatellite instability (MSI) and tumor mutational burden (TMB). RESULTS: One hundred...
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