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Article

Uncovering molecular pathways in appendiceal cancer: A comprehensive characterization for precision oncology.

American journal of surgery - 1 Jul 2026

Lwin Thinzar Min, Waldrup Brigette, Carranza Francisco G, Manjarrez Sophia, Brar Gagandeep, Mannan Rifat, Raoof Mustafa, Velazquez-Villarreal Enrique

Abstract excerpt

OBJECTIVE: Appendiceal cancer (AC) is a rare and understudied gastrointestinal malignancy with a rising incidence. Molecular characterization of this disease is limited. In this work, we analyzed molecular alterations of appendiceal cancer across seven key oncogenic pathways- RTK/RAS, TP53, MAPK, PI3K, TGF-β, WNT and JAK/STAT-stratified by tumor subtype and stage, to identify clinically relevant molecular...

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Identifiers

PMID: 41934711
DOI: 10.1016/j.amjsurg.2026.116941
PMCID: PMC13160183

Genes

TP53
SMAD4
CDKN2A
KIT
RAF1
SOS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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