Article
Molecular profiling of appendiceal epithelial tumors using massively parallel sequencing to identify somatic mutations.
Clinical chemistry - 1 Jul 2014
Liu Xiaoying, Mody Kabir, de Abreu Francine B, Pipas J Marc, Peterson Jason D, Gallagher Torrey L, Suriawinata Arief A, Ripple Gregory H, Hourdequin Kathryn C, Smith Kerrington D, Barth Richard J, Colacchio Thomas A, Tsapakos Michael J, Zaki Bassem I, Gardner Timothy B, Gordon Stuart R, Amos Christopher I, Wells Wendy A, Tsongalis Gregory J
Abstract excerpt
BACKGROUND: Some epithelial neoplasms of the appendix, including low-grade appendiceal mucinous neoplasm and adenocarcinoma, can result in pseudomyxoma peritonei (PMP). Little is known about the mutational spectra of these tumor types and whether mutations may be of clinical significance with respect to therapeutic selection. In this study, we identified somatic mutations using the Ion Torrent AmpliSeq Cancer...
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