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Article

Human Immunotypes Impose Selection on Viral Genotypes Through Viral Epitope Specificity.

The Journal of infectious diseases - 15 Dec 2021

Gabrielaite Migle, Bennedbæk Marc, Zucco Adrian G, Ekenberg Christina, Murray Daniel D, Kan Virginia L, Touloumi Giota, Vandekerckhove Linos, Turner Dan, Neaton James, Lane H Clifford, Safo Sandra, Arenas-Pinto Alejandro, Polizzotto Mark N, Günthard Huldrych F, Lundgren Jens D, Marvig Rasmus L

Abstract excerpt

BACKGROUND: Understanding the genetic interplay between human hosts and infectious pathogens is crucial for how we interpret virulence factors. Here, we tested for associations between HIV and host genetics, and interactive genetic effects on viral load (VL) in HIV-positive antiretroviral treatment-naive clinical trial participants. METHODS: HIV genomes were sequenced and the encoded amino acid (AA) variants were...

Topics

Adult
Epitopes
Female
Genome, Human
Genome, Viral
Genome-Wide Association Study
Genotype
HIV Infections
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Polymorphism, Single Nucleotide

Viral Load

Source

Open in PubMed Open full text

Identifiers

PMID: 33974707
DOI: 10.1093/infdis/jiab253
PMCID: PMC8672757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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