Article
Genome-wide identification of susceptibility alleles for viral infections through a population genetics approach.
PLoS genetics - 19 Feb 2010
Fumagalli Matteo, Pozzoli Uberto, Cagliani Rachele, Comi Giacomo P, Bresolin Nereo, Clerici Mario, Sironi Manuela
Abstract excerpt
Viruses have exerted a constant and potent selective pressure on human genes throughout evolution. We utilized the marks left by selection on allele frequency to identify viral infection-associated allelic variants. Virus diversity (the number of different viruses in a geographic region) was used to measure virus-driven selective pressure. Results showed an excess of variants correlated with virus diversity in...
Topics
- Alleles
- Gene Regulatory Networks
- Genetic Predisposition to Disease
- Genetic Variation
- Genetics, Population
- Genome-Wide Association Study
- Humans
- Polymorphism, Single Nucleotide
- Selection, Genetic
- Virus Diseases