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Article

Membrane prewetting by condensates promotes tight-junction belt formation.

Nature - 1 Aug 2024

Pombo-García Karina, Adame-Arana Omar, Martin-Lemaitre Cecilie, Jülicher Frank, Honigmann Alf

Abstract excerpt

Biomolecular condensates enable cell compartmentalization by acting as membraneless organelles1. How cells control the interactions of condensates with other cellular structures such as membranes to drive morphological transitions remains poorly understood. We discovered that formation of a tight-junction belt, which is essential for sealing epithelial tissues, is driven by a wetting phenomenon that promotes the...

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Identifiers

PMID: 39112699
DOI: 10.1038/s41586-024-07726-0
PMCID: PMC11324514

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PATJ

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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