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Article

Acvr1b Loss Increases Formation of Pancreatic Precancerous Lesions From Acinar and Ductal Cells of Origin.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2024

Saeki Kiyoshi, Wood Ian S, Wang Wei Chuan Kevin, Patil Shilpa, Sun Yanping, Schaeffer David F, Su Gloria H, Kopp Janel L

Abstract excerpt

BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma can develop from precursor lesions, including pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm (IPMN). Previous studies indicated that loss of Acvr1b accelerates the Kras-mediated development of papillary IPMN in the mouse pancreas; however, the cell type predominantly affected by these genetic changes remains unclear. METHODS: We...

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PMID: 39111635
DOI: 10.1016/j.jcmgh.2024.101387
PMCID: PMC11404226

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